5HT 5-R: Product Overview and Specifications

Introduction

The 5HT 5-R is a crucial component in the field of neuroscience research and pharmaceutical development. This entry provides an in-depth overview of the 5HT 5-R, including its product category, basic information, specifications, pin configuration, functional features, advantages and disadvantages, working principles, application field plans, and alternative models.

Product Category

The 5HT 5-R belongs to the category of serotonin receptors, specifically the 5-HT (5-hydroxytryptamine) receptor family. These receptors are G protein-coupled receptors that play a vital role in neurotransmission and are targeted by various pharmaceutical drugs.

Basic Information Overview

• Use: The 5HT 5-R is primarily used in neuroscience research and drug development related to serotonin signaling.
• Characteristics: It exhibits high specificity for serotonin and is involved in modulating various physiological and behavioral functions.
• Package: The 5HT 5-R is typically supplied in vials or microtiter plates, ensuring stability during storage and transportation.
• Essence: As a key player in serotonin signaling, the 5HT 5-R is essential for understanding neurological disorders and developing targeted therapies.
• Packaging/Quantity: The product is commonly available in 1 mg and 5 mg quantities, packaged to maintain purity and activity.

Specifications

• Molecular Weight: Approximately 40 kDa
• Ligand Binding Site: Specific to serotonin (5-HT)
• Expression System: Typically expressed in mammalian cell lines
• Purity: ≥ 95% by SDS-PAGE

Detailed Pin Configuration

The 5HT 5-R consists of seven transmembrane domains with extracellular and intracellular loops. The ligand-binding pocket is located within the transmembrane region, facilitating specific interactions with serotonin.

Functional Features

• Selective Binding: Exhibits high selectivity for serotonin over other neurotransmitters, enabling precise studies of serotoninergic pathways.
• Signal Transduction: Upon ligand binding, the 5HT 5-R initiates intracellular signaling cascades, influencing cellular responses.
• Regulatory Role: Modulates neuronal excitability, synaptic transmission, and hormonal secretion, contributing to diverse physiological processes.

Advantages and Disadvantages

Advantages

• Precise Targeting: Enables specific investigation of serotonin-mediated effects.
• Pharmacological Relevance: Serves as a valuable target for drug discovery and development.
• Research Utility: Facilitates the study of mood disorders, anxiety, and other serotonin-related conditions.

Disadvantages

• Limited Availability: Obtaining pure and active 5HT 5-R samples can be challenging.
• Complex Signaling: The intricate downstream effects of 5HT 5-R activation require comprehensive analysis.

Working Principles

Upon serotonin binding, the 5HT 5-R undergoes conformational changes, leading to the activation of G proteins and subsequent modulation of intracellular signaling pathways. This process influences neuronal excitability, neurotransmitter release, and synaptic plasticity.

Detailed Application Field Plans

The 5HT 5-R finds extensive application in: - Neuropharmacology: Investigating the effects of 5HT 5-R modulators on behavior and cognition. - Drug Development: Screening compounds targeting the 5HT 5-R for potential therapeutic use. - Disease Modeling: Studying the role of 5HT 5-R dysfunction in neuropsychiatric disorders.

Detailed and Complete Alternative Models

In the absence of 5HT 5-R, alternative models such as genetically modified animal models with altered serotonin receptor expression, and in vitro systems utilizing recombinant serotonin receptors, can provide complementary insights into serotonin signaling and pharmacological interventions.

In conclusion, the 5HT 5-R stands as a pivotal tool in unraveling the complexities of serotonin signaling and holds significant promise for advancing neuroscience research and pharmaceutical innovation.

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